Pg 99-465 Trifluoroacetate
Supplier: BACHEM AMERICAS INC
4037992.0500
4037992.1000
H-7292.0500BAEA
422.25
USD
H-7292.0500BA
H-7292.1000BA
Pg 99-465 Trifluoroacetate
Proteins and Peptides
PG 99-465 is a high affinity, selective VPAC2 receptor antagonist. It exhibited a 100-fold preference for the VPAC2 over the VPAC1 receptor. The compound showed partial agonistic activity on the VPAC1 receptor and was inactive on the VPAC2 receptor transfected in CHO cells, as well as on naturally expressed human VPAC2 receptors in the SUP T1 cell line. Dickson et al. observed an agonistic effect of PG99-465 on the human VPAC1 and PAC1 receptors. When applied singly, PG99-465 increased [cAMP](i) at all three hVPAC/PAC receptor subtypes.
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