Human Recombinant IL-27 (from HEK293 Cells)

Supplier: Peprotech

200-38-2UG 200-38-10UG 200-38-50UG 200-38-100UG 200-38-250UG 200-38-500UG 200-38-1MG
10779-920EA 143.41 USD
10779-920 10779-922 10779-924 10779-926 10779-928 10779-930 10779-932
Human Recombinant IL-27 (from HEK293 Cells)
Proteins and Peptides

As a member of the IL-12 family of heterodimeric cytokines that also includes IL-12, IL-23, and IL-35, IL-27 is formed by the association of an IL-27-p28 subunit (also known as IL-30) with the Epstein-Barr Virus (EBV)-induced Gene 3 (EBI3) subunit (also known as IL-27B). Expressed by antigen-presenting cells (APCs) in the early phases of antigen-mediated activation, IL-27 acts as a critical initiator of adaptive immune responses by promoting the rapid clonal expansion of naïve CD4+ T cells, IFN-γ production, and Th1 polarization. IL-27 elicits its effects through receptor complexes IL-27R (also known as TCCR/WSX-1) and gp130, a receptor shared by IL-6. Mainly expressed in monocytes, endothelial cells, and dendritic cells, IL-27 plays an important role alongside IL-6 in the regulation of inflammation and autoimmunity; directly antagonizing IL-6’s stimulation of CD4+ T cell proliferation and Th17 differentiation. Recombinant Human IL-27 produced from


Información para pedidos: For research use only. Not for use in diagnostic or therapeutic procedures.

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