Human Recombinant R-Spondin-2 (from CHO Cells)

Supplier: Peprotech

120-43-5UG 120-43-20UG 120-43-100UG 120-43-250UG 120-43-500UG 120-43-1MG
10779-262EA 143.88 USD
10779-262 10779-264 10779-266 10779-268 10779-270 10779-272
Human Recombinant R-Spondin-2 (from CHO Cells)
Proteins and Peptides

The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally-related, secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization, and resulting accumulation, of the intracellular signaling protein, β-catenin. This activity effectively activates and increases the subsequent nuclear signaling of β-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/β-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations. Recombinant Human R-Spondin-2 is a 24.4 kDa protein consisting of 212 amino acid residues. Due to glycosylation, R-Spondin-2 migrates at an apparent molecular weight of approximately 30.0 kDa by SDS PAGE analysis under reducing conditions.


Información para pedidos: For research use only. Not for use in diagnostic or therapeutic procedures.

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