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Human Recombinant APRIL (from Hi-5 Insect cells)

Supplier: Peprotech

310-10C-2UG 310-10C-10UG 310-10C-50UG 310-10C-100UG 310-10C-250UG 310-10C-500UG 310-10C-1MG

10774-184EA 132.81 USD

10774-184 10774-186 10774-188 10774-190 10774-192 10774-194 10774-196

Human Recombinant APRIL (from Hi-5 Insect cells)

Proteins and Peptides

APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of the colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, competes for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines, including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF-like receptor binding of the APRIL precursor. Recombinant Human APRIL is a soluble 16.3 kDa protein, consisting of 146 amino acid residues.

Información para pedidos: For research use only. Not for use in diagnostic or therapeutic procedures.

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