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Human Recombinant IGF-BP5 (from E. coli)

Supplier: Peprotech

100-05-5UG 100-05-25UG 100-05-100UG 100-05-250UG 100-05-500UG 100-05-1MG

10770-654EA 139.89 USD

10770-654 10770-656 10770-658 10770-660 10770-662 10770-664

Human Recombinant IGF-BP5 (from E. coli)

Proteins and Peptides

IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP5 is a 28.6 kDa, cysteine-rich, secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts, and osteoblasts. Data shows that IGFBP-5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP-5-overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition, and retarded muscle development. Recombinant Human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.

Información para pedidos: For research use only. Not for use in diagnostic or therapeutic procedures.

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