Verapamil hydrochloride, Powder
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Synonyms:
5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile hydrochloride, Verapamil HCl, 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride, (±)-Verapamil hydrochloride
(±)-Verapamil Hydrochloride is a α1-antagonist and calcium channel modulator.
(±)-Verapamil hydrochloride is a calcium channel (L-type) modulator, adrenoceptor antagonist, anti-arrhythmic, cardiac depressant, and coronary vasodilator. It is also a calcium channel-blocker. It acts by inhibiting the slow channel entry of calcium into the cell. It acts by plugging up the channels and limiting the entry of calcium into both smooth muscle cells of arteriolar walls and the ardiac muscle cells at higher doses.
Soluble in water (7 g/100 mL); sparingly soluble in chloroform; soluble in ethanol (26 mg/mL), isopropanol, acetone, ethyl acetate; freely soluble in methanol (> 100 mg/mL), DMF (> 100 mg/mL); practically insoluble in ether.
Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.
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Formula:
C₂₇H₃₈N₂O₄ MW: 491.07 g/mol |
MDL Number:
MFCD00055208 CAS Number: 152-11-4 |
Specification Test Results
| Form | White Powder |
| Storage | Store at Room Temperature (15-30 °C). |
| Extinction Coefficient | EmM = 16.1 (232 nm in ethanol); 6.1 (280 nm in ethanol)(Lit.) |
| pka | 8.6 (Lit.) |
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