Vancomycin hydrochloride (from Streptomyces orientalis), powder
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Synonyms:
(3S,6R,7R,22R,23S,26S,36R,38aR)-3-(2-Amino-2-oxoethyl)-44-[[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy]-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-[[(2R)-4-methyl-2-(methylamino)-1-oxopentyl]amino]-2,5,24,38,39-pentaoxo-22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid xhydrochloride, Vancomycin supplement
Vancomycin inhibits bacterial mucopeptide biosynthesis
- Presentation: White Powder
- Potency: 1000 µg/mg
- Soluble in water (greater than 100 mg/mL). Moderately soluble in dilute methanol. Insoluble in acetone, alcohols, and ether.
- pH: 2.5 - 4.5 (5% aq solution)
Vancomycin is indicated for the treatment of serious, life-threatening infections by Gram-positive bacteria that are unresponsive to other less-toxic antibiotics. In particular, vancomycin should not be used to treat methicillin-sensitive Staphylococcus aureus because it is inferior to penicillins such as nafcillin.
Vancomycin, from Streptomyces orientalis, is used for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (β-lactam-resistant) staphylococci. It is used to block bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It is widely studied in cancer patients.
Glycopeptide antibiotic Mode of action: Used to block bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis by inhibiting incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides.
Antimicrobial spectrum: Gram-positive bacteria.
Vancomycin is a glycopeptide antibiotic that blocks bacterial cell wall biosynthesis at the level of peptidoglycan biosynthesis. It inhibits incorporation of terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. It is effective against Gram-positive bacteria. Vancomycin also alters bacterial-cell-membrane permeability and RNA synthesis.
Soluble in water (>100 mg/mL). Moderately soluble in dilute methanol. Insoluble in acetone, alcohols, and ether.
Precaución: Store under nitrogen
Formula:
C₆₆H₇₅Cl₂N₉O₂₄·HCl MW: 1485.71 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD03613611 CAS Number: 1404-93-9 |
Specification Test Results
Identity Test | Passes |
Potency | ~1000 μg/mg |
FTIR | Conforms to Standard |
pH (5% aq soln) | 2.5-4.5 |
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