Spectinomycin dihydrochloride pentahydrate
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Synonyms:
(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-Trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-benzo[b]pyrano[2,3-e][1,4]dioxin-4-one dihydrochloride pentahydrate
Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It is active against gram-positive and gram-negative bacteria. Spectinomycin binds to the 30S subunit of bacterial ribosomes and suppresses protein synthesis.
- Loss on drying: <20%
Spectinomycin has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media
Spectinomycin inhibits protein synthesis (elongation) by interfering with peptidyl tRNA translocation. Its mode of resistance is by mutation in rpsE (the gene for ribosomal protein S5) and thus prevents binding of spectinomycin.
Spectinomycin also has use in amplification of low copy number plasmid carrying replicons.
White powder
Soluble in water (50 mg/mL), methanol, propyleneglycol; very soluble benzene, chloroform, ethanol and acetone
Formula:
C₁₄H₂₄N₂O₇·2HCl·5H₂O MW: 495.35 g/mol Melting Pt: 205…207 °C Storage Temperature: Refrigerator |
MDL Number:
MFCD00150886 CAS Number: 22189-32-8 |
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