2-Iminothiolane hydrochloride (Traut's Reagent) (synthetic), powder

Supplier: MP BIOMEDICALS (FKA ICN BIOMED

Synonyms: 2-IT HCl, 2-Iminothiolane hydrochloride, 2-Thiolanimine hydrochloride, 2-IT

0215131980 0215131990
IC15131980EA 74.37 USD
IC15131980 IC15131990
2-Iminothiolane hydrochloride (Traut's Reagent) (synthetic), powder
2-Iminothiolane hydrochloride (Traut's Reagent)

2-Iminiothiolane hydrochloride is a thiolating reagent that is used in the preparation of disulfide and thioether linked conjugates, such as for protein crosslinking.


It has a preference for primary amino groups and reacts at pH 7-10 to give amidine compounds which contain free sulhydryl groups. The amidine linkage preserves the original primary amine positive charge. A mechanistic study of the reaction of 2-iminothiolane with amino groups in peptides and proteins has been published. 2-Iminothiolane has also been utilized to prepare glycoprotein-antibody conjugates, streptavidin-antibody conjugates, and avidin-protein nanoparticle conjugates.


Soluble in water (100 mg/mL) and methanol.

Formula: C₄H₈ClNS
MW: 137.625 g/mol
Storage Temperature: Refrigerator
MDL Number: MFCD00039013
CAS Number: 4781-83-3

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