2-Iminothiolane hydrochloride (Traut's Reagent) (synthetic), powder
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Synonyms:
2-IT HCl, 2-Iminothiolane hydrochloride, 2-Thiolanimine hydrochloride, 2-IT
2-Iminiothiolane hydrochloride is a thiolating reagent that is used in the preparation of disulfide and thioether linked conjugates, such as for protein crosslinking.
It has a preference for primary amino groups and reacts at pH 7-10 to give amidine compounds which contain free sulhydryl groups. The amidine linkage preserves the original primary amine positive charge. A mechanistic study of the reaction of 2-iminothiolane with amino groups in peptides and proteins has been published. 2-Iminothiolane has also been utilized to prepare glycoprotein-antibody conjugates, streptavidin-antibody conjugates, and avidin-protein nanoparticle conjugates.
Soluble in water (100 mg/mL) and methanol.
Formula:
C₄H₈ClNS MW: 137.625 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD00039013 CAS Number: 4781-83-3 |
Specification Test Results
Identity Test | Passes |
FTIR | Conforms to Reference |
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