Cytochalasin D (from Zygosporium mansoni), white powder
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
|
Danger
|
Synonyms:
7(S),18(R)-Dihydroxy-16(S),18-dimethyl-10-phenyl[11]cytochalasa-6(12),13(E),19(E)-triene-1,17-dione 21(R)-acetate
Cytochalasin D is a cell permeable fungal toxin that binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. This compound causes the disruption of actin filaments and inhibition of actin polymerization.
Cytochalasin D possesses antibiotic and antitumor activity. It also impairs maintenance of long term potentiation (LTP) of actin filaments. It is implicated in promoting conditions favorable for depolymerizing actin.
Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.
- Presentation: White Powder
- Soluble in chloroform (10 mg/mL - clear, colorless solution), CH2Cl2 (10 mg/ mL - clear colorless solution), DMSO and ethanol.
- Storage temperature: Store at -20 °C, protect from light. Store Dessicated.
Formula:
C₃₀H₃₇NO₆ MW: 507.63 g/mol Melting Pt: 193…195 °C (lit.) Storage Temperature: Freezer |
MDL Number:
MFCD00077706 CAS Number: 22144-77-0 UN: 1544 ADR: 6.1,II |
Specification Test Results
Identity Test | Passes |
Source | Zygosporium mansoni |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...