Amikacin
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections
- Presentation: White Powder
- Optical Rotation: +100.5°
- Sparingly soluble in water
- Loss on drying: <9%
- pH: 9.5 - 11.5 (1% aqueous solution)
Amikacin is most often used for treating infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter.
Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading. It interferes with the translocation of tRNA from the A-site to the P-site.
Amikacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Amikacin must be given by the intravenous or intramuscular route. There is no oral form available as amikacin is not absorbed orally.
Sparingly soluble in water
|
Formula:
C₂₂H₄₃N₅O₁₃ MW: 585.61 g/mol Boiling Pt: 981.8 °C (760 mmHg) Density: 1.6 g/cm³ Storage Temperature: Refrigerator |
MDL Number:
MFCD00883675 CAS Number: 37517-28-5 |
Specification Test Results
| pH (1% aq soln) | 9.5-11.5 |
| Loss on Drying | ≤9% |
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