Actinomycin D (from Streptomyces parvulus) ~98%, crystalline powder
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
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Danger
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Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity.
- Presentation: Red Crystalline Powder
- Soluble in methanol (10 mg/mL - clear, orange solution), soluble in DMSO (50 mg/ mL-clear, orange solution), ethanol, chloroform, benzene, ethyl acetate, propylene glycol, chloroform, acetone, water + glycol mixtures.
Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm′s tumour and the sarcomas.
Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.
Red crystalline
Soluble in methanol (10 mg/mL - clear, orange solution), soluble in DMSO (50 mg/ mL-clear, orange solution), ethanol, chloroform, benzene, ethyl acetate, propylene glycol, chloroform, acetone, water + glycol mixtures.
Precaución: Protect from light
Formula:
C₆₂H₈₆N₁₂O₁₆ MW: 1255.5 g/mol Melting Pt: 251…253 °C (lit.) Storage Temperature: Refrigerator |
MDL Number:
MFCD00005033 CAS Number: 50-76-0 UN: 3462 ADR: 6.1,II |
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