ß-Nicotinamide adenine dinucleotide phosphate tetrasodium salt (NADPH-Na4, reduced form) ≥98%
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Synonyms:
NADPH tetrasodium salt, Sodium (2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-((((((((2R,3S,4R,5R)-5-(3-carbamoylpyridin-1(4H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)oxidophosphoryl)oxy)oxidophosphoryl)oxy)methyl)-4-hydroxytetrahydrofuran-3-yl phosphate, Nicotinamide adenine dinucleotide phosphate tetrasodium salt, (reduced form)
50 mg/ml, clear colorless to slightly yellow solution.
- White Powder
- Store at −0 °C, desiccate, protect from light, store under nitrogen
β-NADPH is a product of the pentose phosphate pathway, a multifunctional pathway whose primary purpose is to generate reducing power in the form of β -NADPH. β-NADPH transfers H+ and 2 e- to oxidized precursors in the reduction reactions of biosynthesis. Thus, β-NADPH cycles between catabolic and biosynthetic reactions and serves as the carrier of reducing power in the same way that ATP serves as the carrier of energy. β-NADPH is also involved with Cytochrome P450 electron transport systems. Enzymes using β-NADPH as a coenzyme include glutathione reductase, diacetyl reductase, dihydrofolate reductase, glutamic dehydrogenase, p-hydroxybenzoate hydroxylase, NADPH-FMN oxidoreductase, nitrate reductase and thioredoxin reductase.
β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).
Electron donor; cofactor for many redox enzymes including nitric oxide synthetase.
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Formula:
C₂₁H₂₆N₇Na₄O₁₇P₃ MW: 833.35 g/mol |
MDL Number:
MFCD00036263 CAS Number: 2646-71-1 |
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Specification Test Results
| Synonyms | β-NADPH; TPNH; Coenzyme II reduced form tetrasodium salt; Dihydronicotinamide-adenine dinucleotide phosphate tetrasodium salt; Triphosphopyridine nucleotide reduced tetrasodium salt |
| Form | White Powder |
| Storage | Store at -0°C, desiccate, protect from light, store under nitrogen. |
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