ß-Nicotinamide adenine dinucleotide phosphate (NADP-Na2, oxidized form) ≥95%
Supplier: MP BIOMEDICALS (FKA ICN BIOMED
Synonyms:
Nadide phosphate disodium salt, Triphosphopyridine nucleotide, disodium salt, NADP-Na2, β-NADP-Na2, NADP disodium salt, Nicotinamide-adenine dinucleotide phosphate disodium salt, 1-((2R,3R,4S,5R)-5-((((((((2R,3R,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-3-carbamoylpyridin-1-ium, disodium salt, β-NADH phosphate disodium salt
Soluble in water (50 mg/l- clear, colorless to slight yellowish solution) or methanol; less soluble in ethanol; practically insoluble in ether and ethyl acetate.
- White powder
β-NADP is a coenzyme necessary for the alcoholic fermentation of glucose and the oxidative dehydrogenation of other substances. It occurs widely in living tissue, especially in the liver. Nicotinic acid can be converted to nicotinamide in the body and, in this form, is found as a component of two oxidation-reduction coenzymes: nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). The nicotinamide portion of the coenzyme transfers hydrogens by alternating between oxidized quaternary nitrogen and a reduced tertiary nitrogen. NADP is an essential coenzyme for glucose-6-phosphate dehydrogenase which catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconic acid. This reaction initiates metabolism of glucose by a pathway other than the citric acid cycle. This route is known as the hexose phosphate shunt or phosphogluconate pathway. Other enzymes which utilize NADP as a coenzyme are: Alcohol dehydrogenase:NADP dependent; Aromatic ADH:NADP dependent; Ferredoxin-NADP reductase; L-Fucose dehydrogenase; Gabase; Galactose-1-phosphate uridyl transferase; Glucose dehydrogenase; L-Glutamic dehydrogenase; Glycerol dehydrogenase:NADP specific; Isocitric dehydrogenase; Malic enzymes; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase and Succinic semialdehyde dehydrogenase.
Nicotinamide adenine dinucleotide phosphate (NADP) and NADPH form a redox pair. NADP/NADPH is a coenzyme that supports redox reactions via the transport of electrons in a vast array of applications, especially anaerobic reactions such as lipid and nucleic acid synthesis. NADP/NADPH is a coenzyme couple in various cytochrome P450 systems and oxidase/reductase reaction systems, such as the thioredoxin reductase/thioredoxin system.
Precaución: Store at -0 °C. Protect from light. Store under nitrogen.
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Formula:
C₂₁H₂₆N₇Na₂O₁₇P₃ MW: 787.37 g/mol Storage Temperature: Refrigerator |
MDL Number:
MFCD00065390 CAS Number: 24292-60-2 |
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Specification Test Results
| Synonyms | β-NADP; TPN; Triphosphopyridine nucleotide; NADP; Coenzyme II;β-NADH phosphate disodium salt;β-NADP-Na2 |
| Form | White Powder |
| Storage | Store at - 0 °C.Protect from light .Store under nitrogen. |
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