Gambogic amide ≥98% (by TLC)
Supplier: Enzo Life Sciences
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Danger
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BML-N159-0001
BML-N159-0005
89160-604EA
163.5
USD
89160-604
89160-606
Gambogic amide ≥98% (by TLC)
Gambogic amide
TrkA ligand
- Formulation: Yellow-orange solid.
A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM.
Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml).
Formula:
C₃₈H₄₅NO₇ Melting Pt: 74…76 °C Storage Temperature: Ambient |
CAS Number:
286935-60-2 |
Specification Test Results
Purity | ≥98% (TLC) |
Appearance | Yellow-orange solid |
Melting Point | 74 - 76°C |
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