Cyclopamine ≥98% (by TLC)

Supplier: Enzo Life Sciences

Cyclopamine ≥98% (by TLC)

Cyclopamine ≥98% (by TLC)

Synonyms: (2'R,3S,3'R,3a'S,6aS,6bS,6'S,7a'R,11aS,11bR)-3',6',10,11b-tetramethyl-1,2,3,3a',4,4',5',6,6a,6b,6',7,7',7a',8,11,11a,11b-octadecahydro-3'H-spiro[benzo[a]fluorene-9,2'-furo[3,2-b]pyridin]-3-ol

BML-GR334-0001 BML-GR334-0005

89158-956EA 163.5 USD

89158-956 89158-958

Cyclopamine ≥98% (by TLC)

Cyclopamine

Blocks Hedgehog signaling

Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. It specifically inhibits the hedgehog (Hh) pathway by interaction with the Hh signaling protein smoothened. Cyclopamine blocks the oncogenic effects of mutations of Ptch in fibroblasts and inhibits the growth of cells lacking Ptch function. It arrested cell cycle at G0/G1 and induced apoptosis in several small-cell lung cancer cell lines at 5 µM. Cyclopamine also induces expression of the transcription factor pdx-1, which stimulates insulin secretion in differentiation protocols for mouse embryonic stem cells

Formula: C₂₇H₄₁NO₂
MW: 411.63 g/mol

MDL Number: MFCD09878269
CAS Number: 4449-51-8

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