Troglitazone ≥98% (by TLC)
Supplier: Enzo Life Sciences
PPAR ligand
Antidiabetic thiazolidinedione. Potent and selective PPARγ ligand. Binds to the PPARγ ligand-binding domain and recruits ligand-specific transcriptional coactivators at 1µM. In skeletal muscle and adipocyte cell cultures, the EC50 of troglitazone is about 10µM. Displaces [125I]SB-236636 with an IC50=7.9 µM. Stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. Induces apoptosis in human vascular smooth muscle cells and inhibits the growth of a variety of human cancer cells including lung, bladder and myeloid leukemia cells.
Synthetic.
Formula:
C₂₄H₂₇NO₅S |
MDL Number:
MFCD00878416 CAS Number: 97322-87-7 |
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