Tyrphostin AG-126 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Synonyms: 2-[(3-Hydroxy-4-nitrophenyl)methylidene]propanedinitrile, Tyrphostin AG 126, 2-(3-Hydroxy-4-nitrobenzylidene)malononitrile, AG-126, (3-Hydroxy-4-nitrobenzylidene)malononitrile

BML-EI263-0005 BML-EI263-0025

89157-912EA 126.44 USD

89157-912 89157-914

Tyrphostin AG-126 ≥98% (by HPLC)

Tyrphostin AG-126

AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

Inhibits tyrosine kinase-dependent B cell receptor signaling

Yellow solid.

Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml warm).

Formula: C₁₀H₅N₃O₃
MW: 215.168 g/mol
Melting Pt: 181…182 °C
Storage Temperature: Ambient

MDL Number: MFCD00236448
CAS Number: 118409-62-4

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