Necrostatin-1 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Synonyms: 5-((1H-Indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one, Nec-1

BML-AP309-0020 BML-AP309-0100
89156-600EA 163.5 USD
89156-600 89156-602
Necrostatin-1 ≥98% (by TLC)
Necrostatin-1

Inhibits necroptosis


Necrostatin-1 inhibits necroptosis, a non-apoptotic cell death pathway. Inhibits the loss of mitochondrial membrane potential in TNFα-treated Jurkat cells (EC50=490 nM). Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. It displays a pronounced protective effect in a mouse model of ischemic brain injury and inhibits myocardial cell death. Inhibits RIP1 kinase the key upstream kinase involved in the activation of necroptosis (EC50=180nM).

Formula: C₁₃H₁₃N₃OS
MW: 259.327 g/mol
MDL Number: MFCD00056916
CAS Number: 4311-88-0
https://digitalassets.avantorsciences.com/adaptivemedia/rendition?id=8550cce9c175c999c89612eca732d475c617a3dc&vid=58b4c2fea13aa0ea1308da4b45b3e8a9274757de&prid=web&clid=SAPDAM

Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR