BAY 41-2272 ≥98%

Supplier: Enzo Life Sciences

BAY 41-2272 ≥98%

BAY 41-2272 ≥98%

Synonyms: 5-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine

420-030-M005 420-030-M025

89150-754EA 163.5 USD

89150-754 89150-756

BAY 41-2272 ≥98%

BAY 41-2272

Guanylyl cyclase activator

NO-independent activator of soluble guanylyl cyclase (sGC). Activates both isoforms alpha1beta1 and alpha1beta2 of sGC. While the related compound YC-1 (Prod. No. ALX-420-025) also acts as a non-specific phosphodiesterase inhibitor, BAY 41-2272 has no effect on phosphodiesterases. Stimulation of sGC is not blocked by high concentrations of NO scavengers (e.g. PTIO, Prod. No. ALX-430-007) and the combination of BAY 41-2272 with the NO donor DEA NONOate (Prod. No. ALX-430-034) potentiates the activation of sGC. Although BAY 41-2272 alone is not as strong a stimulator of sGC as NO, concentrations as low as 10-100nM stimulate sGC to a level that would be expected to cause biologically important increases in cGMP. ODQ (Prod. No. ALX-270-034), a potent and selective inhibitor of sGC, completely inhibited the effect of BAY 41-2272. The activity of BAY 41-2272 is described in selected literature references.

Formula: C₂₀H₁₇FN₆
MW: 360.3876 g/mol

MDL Number: MFCD06411391
CAS Number: 256376-24-6

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