H-1152 dihydrochloride ≥98% (by HPLC)

Supplier: Enzo Life Sciences

H-1152 dihydrochloride ≥98% (by HPLC)

H-1152 dihydrochloride ≥98% (by HPLC)

Synonyms: (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulphonyl]homopiperazine 2HCl, H-1152P 2HCl

270-423-M001 270-423-M005 270-423-M025

89147-860EA 97.01 USD

89147-860 89147-862 89147-864

H-1152 dihydrochloride ≥98% (by HPLC)

H-1152 dihydrochloride

A cell permeable, highly specific, potent and ATP-competitive inhibitor of Rho kinase (ROCK) (Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA, 9.27mM for PKC and 10.1mM for MLCK). More potent and selective than Y-27632. Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid. Inhibits EP3-stimulated NO formation. Prevents fragmentation of apoptotic cells. Relieves neuropathic pain.

ROCK inhibitor

White to off-white solid.

Soluble in water.

Formula: C₁₆H₂₁N₃O₂S·2HCl
MW: 319.4 · 73.0 g/mol
Storage Temperature: Freezer

CAS Number: 45146-2-58-1

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