DAPT ≥98% (by NMR)

Supplier: Enzo Life Sciences

DAPT ≥98% (by NMR)

DAPT ≥98% (by NMR)

Synonyms: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate, (3,5-Difluorophenylacetyl)-Ala-Phg-OtBu, (3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester

270-416-M005 270-416-M025

89147-842EA 163.5 USD

89147-842 89147-844

DAPT ≥98% (by NMR)

DAPT

gamma-Secretase inhibitor

Cell permeable inhibitor of γ-secretase (IC50=115nM for total β-amyloid, IC50=200nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. It blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD)Does not inhibit presenilinase. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling.

Formula: C₂₃H₂₆F₂N₂O₄
MW: 432.47 g/mol

MDL Number: MFCD04974585
CAS Number: 208255-80-5

https://digitalassets.avantorsciences.com/adaptivemedia/rendition?id=e0822edd12088a7a0b4cbfcbdd0616b75ebdfc27&vid=1ee5ecf1a2ad7120aecdba56a4931810fc08d44d&prid=web&clid=SAPDAM

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