B581
Supplier: BACHEM AMERICAS INC
Synonyms:
H-Cys-psi(CH₂NH)Val-psi(CH₂NH)Phe-Met-OH
Sequence: H-Cys-psi(CH₂NH)Val-psi(CH₂NH)Phe-Met-OH
Synonym(s): B581#Farnesyltransferase inhibitor#N-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyl]-Phe-Met-OH
B581, Cys-psi(CH₂NH)-Val- psi[CH₂NH]-Phe-Met is a farnesyltransferase (FTase) inhibitor of special stability and membrane permeability. Due to its high selectivity, B581 is more than 30-fold more active against FTase (IC₅₀ = 21 nM in vitro) than against geranylgeranyltransferase (GGTase). Inhibitors of the farnesyltransferase are potential candidates for the development of anticancer drugs.
Formula:
C₂₂H₃₈N₄O₃S₂ MW: 470.691 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD18910841 CAS Number: 149759-96-6 |
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