Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys -Arg-Arg-NH₂

Supplier: BACHEM AMERICAS INC

4033760.0001 4033760.0005
M-2465.0001BAEA 735.3 USD
M-2465.0001BA M-2465.0005BA
Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys -Arg-Arg-NH₂
Proteins and Peptides

Sequence: Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH₂
Synonym(s): Mca-(Asn⁶⁷⁰,Leu⁶⁷¹)-APP₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide


This fluorescent (FRET) peptide substrate contains the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVNLDAEFRK(Dnp)RR-amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo.


This fluorescent (FRET) peptide substrate contains the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVNLDAEFRK(Dnp)RR-amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo.

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