3,4-Dihydro-2H-pyran-2-ylmethoxymethyl resin 200-400 mesh
Supplier: BACHEM AMERICAS INC
Sequence: 3,4-Dihydro-2H-pyran-2-ylmethoxymethyl resin (200-400 mesh)
Synonym(s): Ellman's dihydropyran resin
This dihydropyran-functionalized resin has been described as an excellent tool for the coupling of primary and secondary as well as functionalized alcohols with high loading levels. The attachment functionality was stable to both strongly basic and nucleophilic reagents. Has been used within the synthesis of ketones from esters and biphenyltetrazole derivatives. Release of the product alcohol from the support is carried out by treating with 95% TFA / 5% water, TFA / CH₂Cl₂ / EtOH or pyridinium p-toluenesulfonate / BuOH / 1,2-dichloroethane.
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