Fmoc-Pro DHPP resin 200-400 mesh

Supplier: BACHEM AMERICAS INC

4019306.0001 4019306.0005
D-1830.0001BAEA 235.2 USD
D-1830.0001BA D-1830.0005BA
Fmoc-Pro DHPP resin 200-400 mesh
Fmoc-Pro

Sequence: Fmoc-Pro-DHPP resin (200-400 mesh)


DHPP-resin, i.e. 4-(1',1'-dimethyl-1'-hydroxypropyl)phenoxyacetyl-alanyl-aminomethyl resin, has been developed especially for the synthesis of peptides containing a C-terminal proline. The bulkiness of the linker prevents diketopiperazine formation. As the esterification of Fmoc-Pro-OH (yielding a modified t-butyl ester) is impeded as well, the resin is offered as loaded derivative. Peptides can be cleaved from this resin applying the standard protocols for the cleavage from Wang resin. Fmoc-Pro-DHPP-resin is an alternative to H-Pro-ClTrt-resin (D-2000) not only if an increased acid stability is required. The resin is more polar than 2-chlorotrityl resin and the Pro residue is more accessible.

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