Fmoc-Asp(OtBu)-(Hmb)Gly-OH
Supplier: BACHEM AMERICAS INC
Please see also the corresponding amino acid derivatives Fmoc-(Dmb)Ala-OH (B-4175), Fmoc-(Dmb)Gly-OH (B-4170), Fmoc-(Hmb)Gly-OH (B-3490), and Fmoc-(Dmb)Leu-OH (B-4165).
Aspartimide formation of the highly base-labile Asp-Gly motif during Fmoc-SPPS may be completely suppressed by coupling this Hmb-protected dipeptide derivative. Additionally, Hmb prevents aggregation of the growing peptide chain as efficiently as the incorporation of a pseudoproline moiety. O-Acylation renders the Hmb moiety acid-stable facilitating the purification of peptides prone to form aggregates. The acyl group can be removed with hydrazine hydrate in DMF (cf. Quibell).
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