Fmoc-Lys(Dde)-OH
Supplier: BACHEM AMERICAS INC
Synonyms:
Nalpha-[(9H-Fluoren-9-ylmethyloxy)carbonyl]-Nepsilon-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl-L-lysine, Fmoc-Lys(Dde)-OH, Fmoc-L-Lys(Dde)-OH, Nalpha-Fmoc-Nepsilon-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl-L-lysine
Sequence: Fmoc-Lys(Dde)-OH
For biotinylated lysine derivatives or chromophores and fluorophores coupled to Lys please see the subfamily "Nε-labeled Lysine".
The Nε-protecting group Dde is orthogonal to both Fmoc and Boc which allows on-resin modification of lysine side chains during Fmoc/tBu-based SPPS. The applications of Dde side-chain protection include synthesis of branched or di-epitopic peptides, preparation of MAP core molecules and lipo-MAPS, the synthesis of cyclic peptides, TASP molecules, and templates for combinatorial chemistry and synthetic proteins. Dde can be cleaved by 2% hydrazine in DMF.
Formula:
C₃₁H₃₆N₂O₆ MW: 532.637 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00278818 CAS Number: 150629-67-7 |
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