Fmoc-Tyr(Malonyl-Di-Otbu)-OH

Supplier: BACHEM AMERICAS INC

4026574.0250 4026574.1000

B-2825.0250BAEA 1323.51 USD

B-2825.0250BA B-2825.1000BA

Fmoc-Tyr(Malonyl-Di-Otbu)-OH

Fmoc-Tyr(Malonyl-Di-Otbu)-OH

Sequence: Fmoc-Tyr(malonyl-di-OtBu)-OH

Besides a large selection of tyrosine derivatives, Bachem offers derivatives of O-alkylated tyrosines, thyronine, phosphotyrosine and sulfotyrosine. Bachem additionally offers H-[¹⁵N]Tyr-OH, E-3245.

The phosphotyrosine-mimicking amino acid Fmoc-Tyr(malonyl-di-OtBu)-OH can be used as a building block for the synthesis of cell-permeable protein tyrosine phosphatase (PTP) inhibitors. The effect of a malonyl-tyrosine containing peptide on PTP 1B catalyzed insulin receptor dephosphorylation has been examined and it was shown that this peptide inhibited PTP 1B 20 times more potently than the corresponding phosphotyrosine containing peptide.

Formula: C₃₅H₃₉NO₉
Storage Temperature: Freezer

MDL Number: MFCD00672344
CAS Number: 168135-77-1

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