H-p-Chloro-Phe-D-Cys-beta-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH₂ Trifluoroacetate
Supplier: BACHEM AMERICAS INC
4044525.0500
4044525.1000
H-6056.0500BAEA
212.39
USD
H-6056.0500BA
H-6056.1000BA
H-p-Chloro-Phe-D-Cys-beta-(3-pyridyl)-Ala-D-Trp-Lys-tBu-Gly-Cys-2-Nal-NH₂ Trifluoroacetate
Proteins and Peptides
PRL2915, Cpa-D-Cys-Pal-D-Trp-Lys-Tle-Cys-Nal-amide, highly potent human somatostatin subtype 2 receptor (hsst2) antagonist with a Ki of 12 nM. Ki values for the other subtypes were >1000 nM for hsst1, 100 ± 57 nM for hsst3, 895 nM for hsst4, and 520 nM for hsst5, respectively. No agonist activity was found when tested alone at concentrations up to 10 µM. In a rat pituitary growth hormone in vitro antagonist assay versus somatostatin-14 (1nM) the somatostatin octapeptide analog PRL2915 exhibited an IC₅₀ value of 1.8 nM.
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