Description: TRC Topotecan Hydrochloride

Catalog Number: 77994-505

Supplier: LGC Standards

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Description: Topotecan hydrochloride 98%

Catalog Number: 77599-772

Supplier: Ambeed

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Description: Potent antitumor agent. Inhibitor of DNA-topoisomerase. Analog of (S)-(+)-camptothecin. Used in chemotherapy of several different cancers.

Catalog Number: 89149-142

Supplier: Enzo Life Sciences

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Description: TRC N-Desmethyl Topotecan

Catalog Number: 77981-986

Supplier: LGC Standards

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Description: Topotecan ≥98%

Catalog Number: 77671-058

Supplier: Ambeed

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Description: Pharmaceutical Standards, (R)-Topotecan

Catalog Number: 77546-972

Supplier: TLC Standards

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Description: Pharmaceutical Standards, Topotecan

Catalog Number: 77475-346

Supplier: TLC Standards

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Description: Organic Standard, Topotecan-d6

Catalog Number: 77695-238

Supplier: LGC Standards

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Description: Pharmaceutical Standards, Topotecan-d6 DiHCl

Catalog Number: 77475-350

Supplier: TLC Standards

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Description: Trimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca2+ by sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by camptothecin (80055-998) and topotecan in HL-60 cells. Heavy metals: <=10ppm.

Catalog Number: 80055-528

Supplier: MilliporeSigma

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Description: An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.

Catalog Number: 77436-882

Supplier: Bioss

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Description: MRP4 transports cyclic nucleotides and anti-retroviral compounds and may be an organic anion pump relevant to cellular detoxification. It is widely expressed, with particularly high levels in prostate, but is barely detectable in liver. It belongs to the ATP binding cassette (ABC) transporter family. MRP4 confers resistance to topotecan and acts as a double agent in protecting the brain from chemotherapy.

Catalog Number: 89367-424

Supplier: Genetex

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Description: An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.

Catalog Number: 77437-636

Supplier: Bioss

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Description: L-Arginine Hydrochloride, Multi-Compendial

Catalog Number: MK4930-09

Supplier: AVANTOR PERFORMANCE MATERIALS US

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Description: Guanidinium hydrochloride, Proteomics Grade

Catalog Number: 97063-766

Supplier: VWR

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Description: L(+)-Cysteine hydrochloride monohydrate, high purity

Catalog Number: 97061-206

Supplier: VWR

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